Fred Sanger, the inventor of the first protein, RNA and DNA sequencing methods, has traditionally been seen as a technical scientist, engaged in laboratory bench work and not interested at all in intellectual debates in biology. In his autobiography and commentaries by fellow researchers, he is portrayed as having a trajectory exclusively dependent on technological progress. The scarce historical scholarship on Sanger partially challenges these accounts by highlighting the importance of professional contacts, institutional and disciplinary moves in his career, spanning (...) from 1940 to 1983. This paper will complement such literature by focusing, for the first time, on the transition of Sanger’s sequencing strategies from degrading to copying the target molecule, which occurred in the late 1960s as he was shifting from protein and RNA to DNA sequencing, shortly after his move from the Department of Biochemistry to the Laboratory of Molecular Biology, both based in Cambridge (UK). Through a reinterpretation of Sanger’s papers and retrospective accounts and a pioneering investigation of his laboratory notebooks, I will claim that sequencing shifted from the working procedures of organic chemistry to those of the emergent molecular biology. I will also argue that sequencing deserves a history in its own right as a practice and not as a technique subordinated to the development of molecular biology or genomics. My proposed history of sequencing leads to a reappraisal of current STS debates on bioinformatics, biotechnology and biomedicine. (shrink)

On 26 June 2000, during the presentation of the Human Genome Project's first draft, Bill Clinton, then President of the United States, claimed that "today we are learning the language in which God created life".1 Behind his remarks lay a story of more than half a century involving the understanding of DNA as information. This paper analyses that story, discussing the origins of the informational view of our genes during the early 1950s, how such a view affected the research on (...) the genetic code (1950s and '60s) and the transformation of the information idea in the context of DNA sequencing and bioinformatics ('80s and '90s). I suggest that the concept of DNA as information reached a climax with the proposal of the Human Genome Project (HGP), but is currently facing a crisis coinciding with the questioning of the information society. Finally, I discuss the emergence of systems biology as an alternative paradigm. (shrink)

This article proposes a new bi-directional way of understanding the convergence of biology and computing. It argues for a reciprocal interaction in which biology and computing have shaped and are currently reshaping each other. In so doing, we qualify both the view of a natural marriage and of a digital shaping of biology, which are common in the literature written by scientists, STS, and communication scholars. The DNA database is at the center of this interaction. We argue that DNA databases (...) are spaces of convergence for computing and biology that change in form, meaning, and function from the 1960s to the 2000s. The first part of the article shows how, in the 1980s, DNA sequencing shifted from passively incorporating computers to be increasingly modeled in digital coding and decoding. Information retrieval algorithms, reciprocally, were altered according to the peculiarities of DNA in the first sequence-storage databases. The second part of the article investigates the impact of these reciprocal interactions and globalization on the organization of research centers, ways of conducting big science, and scientific values. Through convergence and new technologies such as data mining, biology and computing were transformed technologically, institutionally, and culturally into a new bio-data enterprise called genomics. (shrink)

Fred Sanger, the inventor of the first protein, RNA and DNA sequencing methods, has traditionally been seen as a technical scientist, engaged in laboratory bench work and not interested at all in intellectual debates in biology. In his autobiography and commentaries by fellow researchers, he is portrayed as having a trajectory exclusively dependent on technological progress. The scarce historical scholarship on Sanger partially challenges these accounts by highlighting the importance of professional contacts, institutional and disciplinary moves in his career, spanning (...) from 1940 to 1983. This paper will complement such literature by focusing, for the first time, on the transition of Sanger's sequencing strategies from degrading to copying the target molecule, which occurred in the late 1960s as he was shifting from protein and RNA to DNA sequencing, shortly after his move from the Department of Biochemistry to the Laboratory of Molecular Biology, both based in Cambridge (UK). Through a reinterpretation of Sanger's papers and retrospective accounts and a pioneering investigation of his laboratory notebooks, I will claim that sequencing shifted from the working procedures of organic chemistry to those of the emergent molecular biology. I will also argue that sequencing deserves a history in its own right as a practice and not as a technique subordinated to the development of molecular biology or genomics. My proposed history of sequencing leads to a reappraisal of current STS debates on bioinformatics, biotechnology and biomedicine. (shrink)

This paper explores the different identities adopted by connective tissue research at the University of Manchester during the second half of the 20th century. By looking at the long-term redefinition of a research programme, it sheds new light on the interactions between different and conflicting levels in the study of biomedicine, such as the local and the global, or the medical and the biological. It also addresses the gap in the literature between the first biomedical complexes after World War II (...) and the emergence of biotechnology. Connective tissue research in Manchester emerged as a field focused on new treatments for rheumatic diseases. During the 1950s and 60s, it absorbed a number of laboratory techniques from biology, namely cell culture and electron microscopy. The transformations in scientific policy during the late 70s and the migration of Manchester researchers to the US led them to adopt recombinant DNA methods, which were borrowed from human genetics. This resulted in the emergence of cell matrix biology, a new field which had one of its reference centres in Manchester. The Manchester story shows the potential of detailed and chronologically wide local studies of patterns of work to understand the mechanisms by which new biomedical tools and institutions interact with long-standing problems and existing affiliations. (shrink)

Miguel de Unamuno celebra la locura del Quijote como una afirmación del “yo” en su Vida de don Quijote y Sancho. Para G.K. Chesterton la afirmación radical del “yo” es el elemento fundamental de la locura, pero no algo para ser celebrado. Para Chesterton la locura del Quijote no está tanto en la afirmación de su propio “yo” sino en la afirmación de una realidad olvidada, invisible para quienes se han acostumbrado a vivir en un mundo que ha (...) perdido el juicio: es el único cuerdo en un mundo de locos. Elementos de esta lectura del Quijote pueden encontrarse, a pesar de Unamuno, en la Vida de don Quijote y Sancho; es Unamuno, más que el Quijote, quien afirma su “yo” a costa de la realidad. (shrink)

Class, race and gender are three of the most salient factors in society. They determine to an important extent the opportunities we have, e.g. to access public.

Journal of Social Philosophy, EarlyView.

En el planteamiento del problema filosófico de Dios se ponen en juego todas las cuestiones decisivas de la filosofía: la metafísica, la epistemología, la antropología, la ética, etc. La situación histórica del saber filosófico influye además de manera directa en la posibilidad y el modo mismo de ese planteamiento. M. García-Baró, con la circunspección de quien conoce las enormes dificultades entrañadas en el problema, con la competencia de quien conoce de cerca la situación histórica actual de la filosofía, nos (...) introduce en las claves teóricas implicadas en el estado actual de esta espinosa y decisiva cuestión. (shrink)

Los antiguos poetas de Grecia, hombres inspirados, describían nuestra existencia con una serie de rasgos entre los que no solían olvidar, como si éste los resumiera todos por fin, el de el ser que aguanta. No nos atribuían inteligencia, ni práctica ni teórica; tampoco nos concedías potencia para llevar a cabo nuestros planes; menos aún, vida sin fin. Pensaban, más bien, de nosotros que somos soberbios y que la soberbia nos ofusca, y que somos supersticiosos, crueles, avariciosos.

Michel Henry, uno de los representantes del nuevo pensamiento, que comienza convirtiendo a todo el hombre en pura pregunta que atraviesa las capas endurecidas de la verdad tradicional, esta convencido de que la riqueza de la tradición occidental es tan grande que cree que lo esencial de lo que él descubre como lo impensado en Europa se le ha destacado gracias, en buena parte, a la labor magisterial de las figuras mas celebres de la propia filosofía europea. Y esto sucede, (...) sobre todo, con Maine de Biran y Descartes. Lo que pretende defender Henry es que la luz del mundo mismo es el verdadero soporte del videre (ver) cuando el hombre se entrega enteramente en sus manos y piensa como si nada mas hubiera que su relación al mundo. (shrink)

El espectáculo cinematográfico Cinerama es un referente en la tecnología de la gran pantalla. Gracias a Fred Waller y Hazard Reeves, Cinerama elevó su popularidad. Este hecho derivó en la creación de pabellones móviles itinerantes. Cinesa inició en España el desarrollo del Cinerama móvil, ante la falta de salas cinematográficas. Recurrieron, en 1966, a Emilio Pérez Piñero para la realización de un pabellón móvil que imitara Cinerama Dome, obra de Welton Becket, que siguió la patente de la cúpula geodésica de (...) Richard Buckminster Fuller. Sin embargo, Piñero diseñó una patente propia conocida como cúpula reticular de directriz esférica. (shrink)

Grounded theory, a research method born out of the social sciences field, offers a flexible technique that allows simultaneous data collection and processing. Researchers using this method immerse themselves in an area of study, focusing their observations on the data and taking into consideration not only their own interpretations, but also those of the other subjects involved, in order to strengthen their understanding of the social phenomena under examination. This text briefly describes the concept of grounded theory and uses concrete (...) examples to illustrate how data are analysed from the standpoint of the stereotype as an object of study. La teoría fundamentada, nacida al interior de las ciencias sociales, es un método de investigación que posee una técnica flexible y que realiza simultáneamente la recolección y el procesamiento de los datos. En este método, el investigador se encuentra inmerso en el campo de estudio y sus observaciones se abocan al dato, considerando tanto su interpretación como la de los otros sujetos implicados, con la finalidad de fortalecer la comprensión del fenómeno social investigado. En este texto se describe brevemente la teoría fundamentada y cómo se analizan los datos mediante ejemplos concretos, que se presentan a partir del estereotipo como objeto de estudio. (shrink)

This paper aims to analyse how the discourse of CEO letters and other factors influence community involvement and Social Licence to Operate (SLO) in the mining industry. The analysis is based on qualitative information disclosed in sustainability reports and CEO letters from 32 mining firms. Content analysis was undertaken to obtain data for the study, and then a regression analysis and a multiple correspondence analysis were used to test the hypotheses defined in the study. The results indicate that the CEO (...) discourse influences how a firm expresses the importance of gaining its SLO, the philanthropic activities in which companies become involved and the destinations of the investments in the communities in which they operate. The results also show changes in the discourse between 2011 and 2015, which are, in part, explained by the difficult situation experienced by the sector during this period. The paper contributes to the Corporate Social Responsibility literature by integrating different theories from this field into the SLO framework. The analysis carried out and the results obtained are useful for both CEOs and Sustainability Managers, especially in managing their relationships with the communities where they operate or intend to operate. (shrink)

This paper aims to analyse how the discourse of CEO letters and other factors influence community involvement and Social Licence to Operate (SLO) in the mining industry. The analysis is based on qualitative information disclosed in sustainability reports and CEO letters from 32 mining firms. Content analysis was undertaken to obtain data for the study, and then a regression analysis and a multiple correspondence analysis were used to test the hypotheses defined in the study. The results indicate that the CEO (...) discourse influences how a firm expresses the importance of gaining its SLO, the philanthropic activities in which companies become involved and the destinations of the investments in the communities in which they operate. The results also show changes in the discourse between 2011 and 2015, which are, in part, explained by the difficult situation experienced by the sector during this period. The paper contributes to the Corporate Social Responsibility literature by integrating different theories from this field into the SLO framework. The analysis carried out and the results obtained are useful for both CEOs and Sustainability Managers, especially in managing their relationships with the communities where they operate or intend to operate. (shrink)